While standard preventive treatments may reduce the risk of disease flares and organ damage in people with congenital thrombotic thrombocytopenic purpura (TTP), flare-ups can…
Thrombotic thrombocytopenic purpura
Discussion
An Iranian woman with congenital thrombotic thrombocytopenic purpura (TTP) successfully delivered a healthy baby boy after receiving regular infusions of fresh frozen plasma and…
Discussion
Starting plasma exchange — a procedure to replace a portion of a patient’s blood with that of a healthy donor — within one day of…
When a 55-year-old man developed sudden kidney failure, doctors discovered a rare blood-clotting disorder hiding behind a highly unusual genetic profile. A new case report…
Discussion
People in remission from immune-mediated thrombotic thrombocytopenic purpura (iTTP) may have a higher risk of certain major cardiovascular events, particularly stroke, according to a…
Discussion
Four weekly injections of the antibody therapy daratumumab restored a key enzyme’s activity and triggered a two-year recovery for a woman with hard-to-treat immune-mediated…
A 26-year-old woman who arrived at a hospital with lupus and severe thrombocytopenia (very low numbers of blood-clotting platelets) was ultimately diagnosed with immune-mediated…
Discussion
Neutrophil extracellular traps — web-like structures released by immune cells that can promote clotting — are increased during acute episodes and clinical relapses of immune-mediated…
Discussion
Two teenage brothers in Egypt have been diagnosed with an extremely rare combination of two distinct genetic blood-clotting disorders. The boys carry the genetic mutations…
People with congenital thrombotic thrombocytopenic purpura (cTTP) face a substantial burden related to healthcare use and costs, particularly for inpatient admissions directly related to…
